VetCostCalc

Vaccinations Cost in South Carolina (2026)

South Carolina vet costs are 12% below national avg. See exact vaccinations prices, city breakdowns, and how to save.

Vaccination Costs in South Carolina

Vaccine Per dose
Dog DHPP (combo) $31
Dog Rabies $18
Bordetella (kennel cough) $18
Leptospirosis $16
Cat FVRCP $25
Cat Rabies $15
FeLV (feline leukemia) $18

Vet Cost by City in South Carolina

City Wellness Exam
Columbia $58
Charleston $62
Greenville $59
Myrtle Beach $60

Vaccinations Cost in South Carolina — FAQ

How much do dog vaccinations cost in South Carolina?

Annual dog vaccinations in South Carolina cost $90/year in 2026 — 12% below the national average. Core vaccines (DHPP, rabies) are required; non-core vaccines (bordetella, leptospirosis, Lyme) are given based on lifestyle. Puppy series runs $120–$200 total.

How much do cat vaccinations cost in South Carolina?

Annual cat vaccinations in South Carolina average $70/year in 2026. Core cat vaccines include FVRCP and rabies. Indoor cats need fewer vaccines than outdoor cats. Kitten series typically runs $100–$160 total in South Carolina.

Are there low-cost vaccination clinics in South Carolina?

Yes — many PetSmart and Petco locations host low-cost vaccine clinics where core vaccines cost $15–$25 each, vs. $25–$40 at a full-service vet. Humane societies and shelters also offer low-cost vaccine days. A wellness exam is NOT included at vaccine-only clinics.